Monday, September 27, 2010

A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts

Li et al. Cell Stem Cell, Volume 7, Issue 1, 51-63, 17 June 2010

  • Mouse fibroblast reprogramming involves a mesenchymal-to-epithelial transition
  • Sox2, Oct4, and c-Myc suppress TGF-β signaling
  • Klf4 activates multiple epithelial genes including E-cadherin
  • E-cadherin knockdown impairs reprogramming

R&D Systems used in these studies:

Klf4 ChIP from Figure 4 of Li et al.

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