Detection of CCR2 by Flow Cytometry. A. L1.2 mouse pro-B cells transfected with mouse CCR2 were stained with APC-conjugated Mouse CCR2 Monoclonal Antibody (Catalog # FAB5538A; filled histogram) or APC-conjugated Rat IgG2B Isotype Control (Catalog # IC013A; open histogram). B. Mouse peripheral blood cells were stained with APC-conjugated Mouse CCR2 Monoclonal Antibody (Catalog # FAB5538A) and PE-conjugated Mouse Integrin alpha M/CD11b Monoclonal Antibody (Catalog # FAB1124P).
R&D Systems now offers an APC-conjugated Mouse CCR2 Monoclonal Antibody (Catalog # FAB5538A) for flow cytometry. CCR2 is a G protein-linked chemokine receptor that preferentially binds monocyte chemo-attractant protein-1 and -3 (MCP-1/CCL2 and MCP-3/CCL7). Cells that respond to the action of MCP-1, and are therefore likely to express CCR2 receptors, include monocytes, T cells, natural killer cells, basophils, mast cells, and dendritic cells. CCR2, along with other chemokine receptors, is involved in the recruitment of leukocytes to sites of inflammation, making it a potential target for inflammatory disorders. In addition, CCR2 can serve as an HIV fusion co-factor, suggesting that it may also serve as a target for inhibiting the HIV infection process. For more information, please visit our website at www.RnDSystems.com or call 1-800-343-7475.
