Thursday, August 13, 2009

CD47 expression in Leukemia Stem Cells

Expression of the cell-surface protein CD47 allows some normal cells to avoid phagocytosis by macrophages. Two articles in the July 23 issue of Cell from Irving Weissman's Lab at Stanford University show that elevated CD47 expression by leukemic stem cells inhibits macrophage activity and is an indicator of poor prognosis for patients with acute myeloid leukemia.

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis, Jaiswal et al. Cell 138 (2), 271-285 (2009)

CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells, Majeti et al. Cell, 138 (2), 286-299 (2009)

Click here for a list of CD47 products from R&D Systems
hCD47 histogramHuman lymphocytes were stained with PE-conjugated anti-human CD47 (Catalog # FAB4670P, red histogram) or isotype control (Catalog #IC002P, open histogram).

No comments:

Post a Comment

Note: Only a member of this blog may post a comment.